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N-036

Supelco

(±)-Norketamine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (Notação de Hill):
C12H15Cl2NO
Número CAS:
79499-59-5
Peso molecular:
260.16
Código UNSPSC:
41116107
NACRES:
NA.24

grau

certified reference material

Nível de qualidade

300

forma

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

concentração

1.0 mg/mL in methanol (as free base)

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

forensics and toxicology

formato

single component solution

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl.NC1(CCCCC1=O)c2ccccc2Cl

InChI

1S/C12H14ClNO.ClH/c13-10-6-2-1-5-9(10)12(14)8-4-3-7-11(12)15;/h1-2,5-6H,3-4,7-8,14H2;1H

chave InChI

CLPOJGPBUGCUKT-UHFFFAOYSA-N

Categorias relacionadas

Descrição geral

Norketamine is the major urinary metabolite of ketamine. This certified Snap-N-Spike® Solution is suitable for numerous GC/MS or LC/MS applications in forensic analysis, urine drug testing, clinical toxicology, and clinical or diagnostic testing. Ketamine, sold as Ketanest®, Ketaset® and Ketalar®, is an NMDA receptor antagonist used for the induction and maintenance of general anesthesia in human and veterinary medicine. The drug is often abused at clubs, raves, or parties for its noted hallucingenic and dissociative properties and prescribed by some doctors as an off-label treatment for depression.

Aplicação


  • Pharmacokinetics of ketamine following a short intravenous infusion to isoflurane-anesthetized New Zealand White rabbits: This study employs (±)-Norketamine hydrochloride to examine the pharmacokinetics of ketamine, providing critical insights into its metabolic pathways and implications for anesthetic use in veterinary medicine (Luca et al., 2020).

  • Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy: Research utilizing (±)-Norketamine hydrochloride explores its pharmacological properties compared to ketamine, enhancing the understanding of its safety and efficacy in clinical settings, which is crucial for the development of anesthetic protocols (Wang et al., 2019).

  • The acute and residual effects of escalating, analgesic-range doses of ketamine on driving performance: This innovative study leverages (±)-Norketamine hydrochloride to investigate the effects of ketamine on motor skills and cognitive functions, contributing to discussions on public safety and clinical use of psychoactive compounds (Hayley et al., 2018).

  • Ketamine metabolites with antidepressant effects: This research highlights the role of (±)-Norketamine hydrochloride in identifying ketamine metabolites with potential antidepressant effects, thus expanding its applications beyond anesthetic use to potentially treat mood disorders (Fassauer et al., 2017).

  • Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs: Utilizing (±)-Norketamine hydrochloride, this study aims at developing new ketamine analogs that could offer benefits such as reduced side effects and shorter duration of action, pivotal for both clinical and therapeutic applications (Harvey et al., 2015).

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Ketalar is a registered trademark of Par Sterile Products, LLC
Ketanest is a registered trademark of Pfizer, Inc.
Ketaset is a registered trademark of Zoetis W LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órgãos-alvo

Eyes,Central nervous system

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

49.5 °F - closed cup

Ponto de fulgor (°C)

9.7 °C - closed cup

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