A-917

7-Aminoclonazepam-d₄ solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (Notação de Hill): C₁₅D₄H₈ClN₃O
• Número CAS: 1215070-96-4
• Peso molecular: 289.75
• Número CE: 200-835-2
• Número MDL: MFCD01076479
• Código UNSPSC: 41116107
• ID de substância PubChem: 329771040
• NACRES: NA.24

Propriedades

• grau: certified reference material
• Nível de qualidade: 300
• Formulário: liquid
• Características: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• embalagem: ampule of 1 mL
• fabricante/nome comercial: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland)
• concentração: 100 μg/mL in acetonitrile
• técnica(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• aplicação(ões): clinical testing
• Formato: single component solution
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C1NC2=CC=C(N)C=C2C(C3=C([2H])C([2H])=C([2H])C([2H])=C3Cl)=NC1
• InChI: 1S/C15H12ClN3O/c16-12-4-2-1-3-10(12)15-11-7-9(17)5-6-13(11)19-14(20)8-18-15/h1-7H,8,17H2,(H,19,20)/i1D,2D,3D,4D
• chave InChI: HEFRPWRJTGLSSV-RHQRLBAQSA-N

Descrição

Descrição geral

An internal standard suitable for use in LC/MS or GC/MS testing methods of 7-aminoclonazepam for clinical toxicology, pain prescription monitoring, forensic analysis, or isotope dilution methods. 7-Aminoclonazepam is a major metabolite of clonazepam, a potent, long-acting benzodiazepine marketed as Klonopin^® in the US and Rivotril in many other countries.

Aplicação

• Matrix Effects in Forensic Toxicology: 7-Aminoclonazepam-d₄ serves as an internal standard in studying matrix effects in forensic toxicology, enhancing the analysis of hyperlipidemic postmortem blood. This research supports the importance of precise quantification of drugs in complex biological matrices (Elenstål et al., 2023).


• Benzodiazepine Analysis in Various Matrices: The compound is used as an internal standard in comparative studies of postmortem concentrations of benzodiazepines across different biological matrices. This facilitates a broader understanding of drug distribution and postmortem redistribution phenomena (Øiestad et al., 2023).


• Stability Studies in Analytical Chemistry: Employed in the corrigendum addressing the stability of 7-aminoclonazepam under frozen storage conditions, 7-Aminoclonazepam-d₄ is critical for ensuring the reliability of long-term substance stability studies, highlighting its utility in clinical mass spectrometry (Dahlin and Petrides, 2022).


• Drug Detection in Oral Fluid: This internal standard is essential for the rapid extraction and qualitative screening of drugs in oral fluid, particularly in driving under the influence of drugs (DUID) cases, demonstrating its role in law enforcement and forensic applications (Coulter et al., 2022).


• Comparison of Screening Methods: 7-Aminoclonazepam-d₄ is utilized in evaluating the efficacy of immunoassay screening methods versus LC-MS/MS for detecting traditional and designer benzodiazepines in urine, contributing to advancements in toxicological analysis (Rossi et al., 2021).

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Klonopin is a registered trademark of Hoffmann-La Roche Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS02,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H302 + H312 + H332,H319
• Declarações de precaução: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 35.6 °F - closed cup
• Ponto de fulgor (°C): 2.0 °C - closed cup