870604P
Avanti
oxPAPC
Avanti Research™ - A Croda Brand 870604P, powder
Sinônimo(s):
oxPAPC, Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
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About This Item
Código UNSPSC:
12352211
NACRES:
NA.25
Produtos recomendados
forma
powder
embalagem
pkg of 1 × 500 μg (870604P-500ug)
fabricante/nome comercial
Avanti Research™ - A Croda Brand 870604P
tipo de lipídio
phosphoglycerides
phospholipids
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
Descrição geral
Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is a mixture of oxidized phospholipid and a bioactive constituent of oxidized low-density lipoproteins (LDLs).
Aplicação
Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is suitable for use to stimulate murine alveolar macrophages in vitro. It is also suitable for use to study its effects on human aortic endothelial cell metabolic reprogramming.
Ações bioquímicas/fisiológicas
Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) show barrier-protective effects on human pulmonary endothelial monolayers. This lipid induce endothelial dysfunction by stimulating both pro- and anti-inflammatory pathways. OxPAPC is highly accumulated in atherosclerotic lesions and other sites of chronic inflammation.
Embalagem
5 mL Clear Glass Sealed Ampule (870604P-500ug)
Informações legais
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Certificados de análise (COA)
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Corinne M Spickett et al.
Free radical biology & medicine, 51(12), 2133-2149 (2011-10-11)
Phospholipids are complex and varied biomolecules that are susceptible to lipid peroxidation after attack by free radicals or electrophilic oxidants and can yield a large number of different oxidation products. There are many available methods for detecting phospholipid oxidation products
Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC
Li R, et al.
Circulation Research, 98(5), 642-650 (2006)
Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury
Dubey PK, et al.
International Immunology, 29(2), 79-85 (2017)
Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
Birukov KG, et al.
Microvascular Research, 67(1), 18-28 (2004)
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Hitzel J, et al.
Nature Communications, 9(1), 2292-2292 (2018)
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