936529

(S,R,S)-AHPC-CO-PEG4-C2-acid

≥95%

• Sinônimo(s): (S)-18-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidine-1-carbonyl]-19,19-dimethyl-16-oxo-4,7,10,13-tetraoxa-17-azaicosanoic acid, (S)-18-[[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-yl]carbonyl]-19,19-dimethyl-16-oxo-4,7,10,13-tetraoxa-17-azaicosanoic acid, L-Prolinamide, N-(15-carboxy-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• Fórmula empírica (Notação de Hill): C₃₄H₅₀N₄O₁₀S
• Número CAS: 2172820-12-9
• Peso molecular: 706.85
• Número MDL: MFCD32693336
• Código UNSPSC: 12352106

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95%
• forma: powder or crystals
• cor: White to Beige
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: C([C@@H](NC(CCOCCOCCOCCOCCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Descrição

Aplicação

(S,R,S)-AHPC-CO-PEG4-C2-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

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Outras notas

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Informações legais

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable