930652

Pomalidomide-C₂-NH₂ hydrochloride

≥95%

• Sinônimo(s): 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, E3 Ligase Ligand 17
• Fórmula empírica (Notação de Hill): C₁₅H₁₆N₄O₄ · xHCl
• Número CAS: 2305369-00-8
• Peso molecular: 316.31 (free base basis)
• Número MDL: MFCD31730839
• Código UNSPSC: 12352101
• NACRES: NA.21

Propriedades

• ligand: pomalidomide
• Nível de qualidade: 100
• Ensaio: ≥95%
• forma: powder
• grupo funcional: amine
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCN)=CC=C3)=O)=O.Cl

Descrição

Aplicação

Pomalidomide-C₂-NH₂ Hydrochloride is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with carboxyl linkers due to the presence of an amine group via peptide coupling reactions. It is also active for linker attachment via reductive amination, and a basic building block for development of a protein degrader library.


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Outras notas

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informações legais

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable