933570
NanoFabTx™- Maleimide Lipid Mix
for synthesis of maleimide-functionalized liposomes
Sinônimo(s):
Cholesterol, DSPC-PEG-Maleimide, HSPC
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About This Item
Código UNSPSC:
12352211
NACRES:
NA.21
Produtos recomendados
Nível de qualidade
temperatura de armazenamento
−20°C
Aplicação
NanoFabTx™ Maleimide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of maleimide-functionalized liposomes. Maleimide is a stable and easy-to-handle moiety that rapidly and covalently conjugates thiol groups of cysteine residues in proteins or peptides. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with maleimide groups using extrusion and microfluidics are also included. The synthesized maleimide-functionalized liposomes enable facile conjugation of targeting groups like proteins, peptides, and other thiol-containing moieties onto the liposome surface for targeted drug delivery.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with maleimide groups using extrusion and microfluidics are also included. The synthesized maleimide-functionalized liposomes enable facile conjugation of targeting groups like proteins, peptides, and other thiol-containing moieties onto the liposome surface for targeted drug delivery.
Características e benefícios
- A ready-to-use nanoformulation lipid blend for the synthesis of maleimide-functionalized liposomes
- Step-by-step protocols developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- Maleimide surface functionalization allows for targeting ligand and protein conjugation to enable targeted drug delivery
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
Informações legais
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
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Hanmei Li et al.
Journal of biomedical nanotechnology, 17(12), 2382-2390 (2022-01-04)
Albumin, the most abundant protein in plasma, has been widely used in drug delivery studies. Here, we developed maleimide-functionalized liposomes (Mal-Lip) that can bind to endogenous albumin to improve the tumor targeting efficiency of liposomes. Transmission electron microscopy and gel
Mira Oswald et al.
International journal of pharmaceutics, 514(1), 93-102 (2016-11-20)
Numerous examples exist in the literature for the use of maleimide-thiol-reactions in the area of functionalized nanoparticles. Although the hydrolysis tendency of maleimides is well-known, qualitative and quantitative information on the stability and reactivity of maleimide groups during preparation and
Tianshu Li et al.
International journal of nanomedicine, 9, 2849-2861 (2014-06-19)
With a small amount of maleimide modification on the liposome surface, enhanced cellular uptake of liposomes and drug-delivery efficiency can be obtained both in vitro and in vivo. Herein, we describe the mechanisms underlying this enhanced cellular uptake. Suppression of
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