926248
Redox Responsive Poly(ethylene glycol)-block-poly(lactide-alt-glycolide)
PEG average Mn 5000, PLGA Mn 15000
Sinônimo(s):
Drug release, PEG-PLGA with disulfide linkage, PEG-SS-PLGA, Stimuli-responsive
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About This Item
Fórmula linear:
CH3O(C2H4O)nC7H12O4S2(C5H6O4)m
Código UNSPSC:
12352112
Produtos recomendados
forma
powder, chunks or granules
Nível de qualidade
peso molecular
PEG average Mn 5000
PLGA Mn 15000
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
O=C(C(C)OC(CO[H])=O)OCCSSCCOC(OCCOCCOC)=O
Categorias relacionadas
Aplicação
PEG-SS-PLGA is a redox responsive, biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(lactide-alternative-glycolide) (PLGA) block, with a reducible disulfide linkage between blocks. This polymer can be fabricated into Glutathione (GSH) responsive nanoparticles which can be used as an intracellular drug delivery system.
Different from common Poly(lactide-co-glycolide) (PLGA) polymer, the lactic and glycolic units in Poly(lactide-alt-glycolide) block alternate in sequence in the polymer chain, and the molar ratio of lactic to glycolic units in the polymer is exactly 1:1.
Poly(lactide-alt-glycolide) exhibits excellent solubility in common organic solvents, such as acetonitrile, acetone, dioxane, DCM, and THF, providing great convenience for drug delivery researches and applications.
Different from common Poly(lactide-co-glycolide) (PLGA) polymer, the lactic and glycolic units in Poly(lactide-alt-glycolide) block alternate in sequence in the polymer chain, and the molar ratio of lactic to glycolic units in the polymer is exactly 1:1.
Poly(lactide-alt-glycolide) exhibits excellent solubility in common organic solvents, such as acetonitrile, acetone, dioxane, DCM, and THF, providing great convenience for drug delivery researches and applications.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Lin Yu et al.
Biomacromolecules, 12(4), 1290-1297 (2011-03-03)
This paper reports the influence of sequence structures of block copolymers composed of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) on their thermogelling aqueous behaviors. A series of thermogelling PLGA-PEG-PLGA triblock copolymers with similar chemical compositions and block lengths
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