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901422

Sigma-Aldrich

Poly(N-isopropylacrylamide)

average Mn 85,000

Sinônimo(s):

NIPAM polymer, PNIPAM, PolyNIPAM, Polyacrylamide, polyNIPAM

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About This Item

Fórmula linear:
CH3(C6H11NO)nCH3
Número CAS:
25189-55-3
Número MDL:
MFCD00284282
Código UNSPSC:
12162002
NACRES:
NA.23

Formulário

crystals

peso molecular

Mn 60,000-110,000 Da by MALLS (GPC)
average Mn 85,000

cor

white to off-white

pf

96 °C

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(C)NC(=O)C=C

InChI

1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)

chave InChI

WDFKEEALECCKTJ-UHFFFAOYSA-N

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Descrição geral

Poly(N-isopropylacrylamide) (PNIPAM) is a temperature-responsive polymer used in biomedical research applications. PNIPAM undergoes a reversible, lower critical solution temperature (LCST) phase transition when heated above 32 °C, transitioning from a soluble to an insoluble material. PNIPAM is also frequently crosslinked to yield hydrogels with reversible, thermal shrinking and swelling. Poly(N-isopropylacrylamide) is also readily functionalized and has been used as the hydrophilic block in the synthesis of thermoresponsive, amphiphilic block copolymers. Due to the similarity in temperature between the LCST of PNIPAM and the temperature of the human body, PNIPAM materials have been frequently utilized in tissue engineering and controlled drug delivery research applications.

Aplicação

PNIPAM can be used in the formation of a smart hydrogel, which finds potential usage in sensors, fuel cells, supercapacitors, and lithium-ion batteries. It can also be used in the fabrication of molecular nanothermometer. PNIPAM is coated with gold nanoparticles (AuNPs) to form microgels that facilitate highly reproducible signals for surface-enhanced Raman scattering (SERS).
Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
MKCJ4783

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Au@ pNIPAM colloids as molecular traps for surface-enhanced, spectroscopic, ultra-sensitive analysis
Alvarez-Puebla RA, et al.
Angewandte Chemie (International ed. in English), 48(1), 138-143 (2009)
S Panja et al.
ACS applied materials & interfaces, 8(19), 12063-12074 (2016-04-30)
The design of nanomedicines from the tuned architecture polymer is a leading object of immense research in recent years. Here, smart thermoresponsive micelles were prepared from novel architecture four-arm star block copolymers, namely, pentaerythritol polycaprolactone-b-poly(N-isopropylacrylamide) and pentaerythritol polycaprolactone-b-poly(N-vinylcaprolactam). The polymers
Synthesis of hyperbranched polyglycidol-b-poly(N-isopropylacrylamide) using nitroxide-mediated polymerization for thermo-sensitive drug delivery system.
Min Seon Heo et al.
Journal of controlled release : official journal of the Controlled Release Society, 213, e80-e80 (2016-03-24)
Muhammad Abdul Haq et al.
Materials science & engineering. C, Materials for biological applications, 70(Pt 1), 842-855 (2016-10-25)
Materials which adjust their properties in response to environmental factors such as temperature, pH and ionic strength are rapidly evolving and known as smart materials. Hydrogels formed by smart polymers have various applications. Among the smart polymers, thermoresponsive polymer poly(N-isopropylacrylamide)(PNIPAM)
Nanorod-coated PNIPAM microgels: thermoresponsive optical properties
Karg M, et al.
Small, 3(7), 1222-1229 (2007)
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