About This Item
Fórmula linear:
H2NC(O)C6H4CO2H
Número CAS:
Peso molecular:
165.15
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
NACRES:
NA.22
Produtos recomendados
Nível de qualidade
Ensaio
97%
Formulário
solid
pf
140-143 °C (lit.)
grupo funcional
amide
carboxylic acid
cadeia de caracteres SMILES
NC(=O)c1ccccc1C(O)=O
InChI
1S/C8H7NO3/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H2,9,10)(H,11,12)
chave InChI
CYMRPDYINXWJFU-UHFFFAOYSA-N
Descrição geral
Phthalamic acid can be synthesized from the reaction between ammonia and phthalic anhydride by a modified Auger′s method. Kinetic studies of the intramolecular carboxylic-group assisted hydrolysis of amide bond of phthalamic acid provided the value of pseudo-first order rate constant (kobs) as 5.1×10-5sec-1 at pH 1.3-1.8 and 35°C. It undergoes hydrolysis about 105 times faster than benzamide.
Aplicação
Phthalamic acid may be used to synthesize anthranilic acid via reaction with sodium hypochlorite.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órgãos-alvo
Respiratory system
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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?General acid-base catalysis in the intramolecular hydrolysis of phthalamic acid1?
Bender L M
Journal of the American Chemical Society, 79(5), 1258-1259 (1957)
CCXXXVII.?The preparation of phthalamic acids and their conversion into anthranilic acids.
Chapman E and Stephen E.
Journal of the Chemical Society, 127, 1791-1797 (1925)
Mireille Canal-Raffin et al.
Particle and fibre toxicology, 4, 8-8 (2007-09-22)
Pesticides, in particular folpet, have been found in rural and urban air in France in the past few years. Folpet is a contact fungicide and has been widely used for the past 50 years in vineyards in France. Slightly water-soluble
The hydrolysis and cyclization of some phthalamic acid derivatives.
J Brown et al.
Journal of the American Chemical Society, 88(19), 4468-4474 (1966-10-05)
Yoshiyuki Ogino et al.
Chirality, 29(6), 282-293 (2017-04-20)
Enantiomeric thalidomide undergoes various kinds of biotransformations including chiral inversion, hydrolysis, and enzymatic oxidation, which results in several metabolites, thereby adding to the complexity in the understanding of the nature of thalidomide. To decipher this complexity, we analyzed the multidimensional
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