49920

Glycerol formal

≥98.0% (GC)

• Sinônimo(s): 1,3(or 2,3)-O-Methylene-1,2,3-propanetriol
• Fórmula empírica (Notação de Hill): C₄H₈O₃
• Número CAS: 99569-11-6
• Peso molecular: 104.10
• Beilstein: 103206
• Número MDL: MFCD10039829
• Código UNSPSC: 12352100
• ID de substância PubChem: 57651229
• NACRES: NA.22

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥98.0% (GC)
• contém: ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer
• composição: 5-hydroxy-1,3-dioxane, ~60% ; 4-hydroxymethyl-1,3-dioxolane, ~40%
• índice de refração: n20/D 1.451 (lit.); n20/D 1.451
• pb: 192-193 °C (lit.)
• densidade: 1.203 g/mL at 25 °C (lit.)
• grupo funcional: ether; hydroxyl
• cadeia de caracteres SMILES: OCC1COCO1.OC2COCOC2
• InChI: 1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2
• chave InChI: JIUMSISXCKWZTA-UHFFFAOYSA-N

Descrição

Descrição geral

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

Aplicação

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.

Informações de segurança

• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: Eyeshields, Gloves, type ABEK (EN14387) respirator filter