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275611

Sigma-Aldrich

Rhein

technical grade

Sinônimo(s):

4,5-Dihydroxyanthraquinone-2-carboxylic acid, 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, Cassic acid, Chrysazin 3-carboxylic acid, Monorhein, Rheic acid, Rhubarb yellow

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About This Item

Fórmula empírica (Notação de Hill):
C15H8O6
Número CAS:
478-43-3
Peso molecular:
284.22
Beilstein:
2222155
Número CE:
207-521-4
Número MDL:
MFCD00009618
Código UNSPSC:
12352100
ID de substância PubChem:
24856659
NACRES:
NA.22

grau

technical grade

Nível de qualidade

100

pf

≥300 °C (lit.)

grupo funcional

carboxylic acid
ketone

cadeia de caracteres SMILES

OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI

1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

chave InChI

FCDLCPWAQCPTKC-UHFFFAOYSA-N

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Descrição geral

The pharmakokinetics of Rhein was studied.

Aplicação

Rhein was used to induce necrosis-apoptosis switch in injured pancreatic acinar cells.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
STBJ8429
STBH9022
STBG0962V
STBF3757V
STBD2039V

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Xianlin Zhao et al.
Evidence-based complementary and alternative medicine : eCAM, 2014, 404853-404853 (2014-06-25)
Objectives. The Chinese herbal medicine Da-Cheng-Qi decoction can regulate a necrosis-apoptosis switch in injured pancreatic acinar cells. This study investigated the effects of rhein, a component of this medicine, on a necrosis-apoptosis switch in pancreatic rat AR42J cells. Methods. Cerulein-treated
Yun-Liang Yan et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 39(3), 520-525 (2014-06-21)
This study aim to reveal the total pharmacokinetics of rhein and chrysophanol after oral administration of Quyu Qingre granules (QUQRG) in normal and acute blood stasis rabbits, to identify the pharmacokinetics differences between two groups of rabbits and to evaluate
Baoen Chen et al.
Journal of the American Chemical Society, 134(43), 17963-17971 (2012-10-11)
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N(6)-methyladenosine (m(6)A) residues in mRNA in vitro and inside cells. FTO is the first RNA demethylase discovered that also serves a major regulatory function in mammals. Together with
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The tumor microenvironment (TME) consists of different cell types, including tumor-associated macrophages (TAMs) and tumor-associated fibroblasts (TAFs). How these cells interact and contribute to lung carcinogenesis remains elusive. Using G12DKRAS- and V600EBRAF-driven mouse lung models, we identify the pleiotropic glycoprotein
Tom Coenye et al.
Antimicrobial agents and chemotherapy, 51(4), 1541-1544 (2007-01-16)
We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our results suggest that AQs
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Global Trade Item Number

SKUGTIN
275611-10G
275611-50MG4061826168912
275611-1G
275611-250MG4061826168899

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