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142360

Sigma-Aldrich

4-Benzylpiperidine

99%

Sinônimo(s):

Phenyl(4-piperidyl)methane

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About This Item

Fórmula empírica (Notação de Hill):
C12H17N
Número CAS:
31252-42-3
Peso molecular:
175.27
Beilstein:
132339
Número CE:
250-535-0
Número MDL:
MFCD00006006
Código UNSPSC:
12352100
ID de substância PubChem:
24848521
NACRES:
NA.22

Ensaio

99%

índice de refração

n20/D 1.537 (lit.)

p.e.

279 °C (lit.)

pf

6-7 °C (lit.)

densidade

0.997 g/mL at 25 °C (lit.)

grupo funcional

phenyl

cadeia de caracteres SMILES

C1CC(CCN1)Cc2ccccc2

InChI

1S/C12H17N/c1-2-4-11(5-3-1)10-12-6-8-13-9-7-12/h1-5,12-13H,6-10H2

chave InChI

ABGXADJDTPFFSZ-UHFFFAOYSA-N

Informações sobre genes

rat ... Htr2a(29595) , Htr2c(25187)

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Descrição geral

4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.

Aplicação

4-Benzylpiperidine was used to study the metabolism of 1,3-butadiene and its oxidized metabolites in perfused livers of male B6C3F1 mice and Sprague-Dawley rats.
Reactant for synthesis of:
  • Antiproliferatives
  • GABA uptake inhibitors
  • Pyridines
  • Histamine H3 antagonists
  • Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
  • Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution

Ações bioquímicas/fisiológicas

4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

233.6 °F - closed cup

Ponto de fulgor (°C)

112 °C - closed cup

Equipamento de proteção individual

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
12903TH
S43132
14111HH
08921CH
05316CH

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Johannes G Filser et al.
Toxicological sciences : an official journal of the Society of Toxicology, 114(1), 25-37 (2009-12-17)
The industrial chemical 1,3-butadiene (BD) is a potent carcinogen in mice and a weak one in rats. This difference is generally related to species-specific burdens by the metabolites 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 3,4-epoxy-1,2-butanediol (EBD), which are all formed in
Y Arai et al.
Neuroscience letters, 70(2), 255-260 (1986-10-08)
Inhibitory effects of some MPTP and MPP+ analogues on rat brain MAO activity were studied to further clarify the structure-activity relationships of MPTP neurotoxicity. Of the analogues tested, 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine (CPTP), 4-(4-chlorobenzyl)-pyridine (CBP), 4-benzylpyridine (BPY) and 4-benzylpiperidine (BPIP) dose-dependently inhibited both
Sindhu S Ganti et al.
International journal of pharmaceutics, 550(1-2), 71-78 (2018-08-21)
The objective of our study was to develop a transdermal patch of 4-benzylpiperidine and to evaluate its in vitro transdermal permeation profile. Appropriate pressure sensitive adhesives and additives were selected based on solubility and slide crystallization studies. Release liners and
S S Negus et al.
The Journal of pharmacology and experimental therapeutics, 329(1), 272-281 (2009-01-20)
Monoamine releasers constitute one class of drugs currently under investigation as potential agonist medications for the treatment of cocaine dependence. The efficacy and safety of monoamine releasers as candidate medications may be influenced in part by their relative potency to

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