TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
Sinônimos:
APO2L, Apo-2L, CD253, TL2, TRAIL
Espécies:
Human TNFSF10 (8743), Mouse Tnfsf10 (22035), Rat Tnfsf10 (246775), Zebrafish tnfsf10 (436866), domestic cat TNFSF10 (100174789), domestic cat TNFSF10 (101083289), dog TNFSF10 (100174780), chicken TNFSF10 (378894), cow TNFSF10 (507215), sheep TNFSF10 (101114153) ...Mais
ID UniProtKB:
ID do gene:
- Human(8743) Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Mouse(22035) tumor necrosis factor (ligand) superfamily, member 10
- Rat(246775) tumor necrosis factor (ligand) superfamily, member 10
- Zebrafish(436866) tumor necrosis factor (ligand) superfamily, member 10
- domestic cat(100174789) tumor necrosis factor (ligand) superfamily, member 10
- domestic cat(101083289) tumor necrosis factor (ligand) superfamily, member 10
- dog(100174780) tumor necrosis factor (ligand) superfamily, member 10
- chicken(378894) tumor necrosis factor (ligand) superfamily, member 10
- cow(507215) tumor necrosis factor (ligand) superfamily, member 10
- sheep(101114153) tumor necrosis factor (ligand) superfamily, member 10
- domestic guinea pig(100734497) tumor necrosis factor (ligand) superfamily, member 10
- naked mole-rat(101702439) tumor necrosis factor (ligand) superfamily, member 10
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Antibodies
Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-TRAIL/CD253 Antibody, clone 6D12.2, clone 6D12.2, from mouse,
Reatividade de espécies
human
Aplicação
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-TNFSF10 antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
western blot
Anti-TNFSF10 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-CD253 antibody produced in mouse, clone 2E5,
Reatividade de espécies
human
Aplicação
flow cytometry
Anti-Trail antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Número do produto
Descrição
Espécies
TRAIL Protein, Recombinant human, Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.,
Espécies
human
TRAIL, Soluble human, recombinant, expressed in E. coli, His tagged, >98% (SDS-PAGE),
Espécies
human
TRAIL human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder,
Espécies
human
TRAIL human, recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder,
Espécies
human
TRAIL from mouse, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Espécies
mouse