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Merck

PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Sinônimos:
DOD, UBL5
Espécies:
ID UniProtKB:
ID do gene:
  • Human(5300) Summary: Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
  • Mouse(23988) protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
  • Rat(298696) peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • Thale Cress(843693) auxin efflux carrier component 1
  • Zebrafish(393721) protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
  • domestic cat(101087904) peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • dog(484963) peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • chicken(100859153) peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • naked mole-rat(101708402) peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • domestic guinea pig(100726337) peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • cow(535470) peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • sheep(101110756) peptidylprolyl cis/trans isomerase, NIMA-interacting 1

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-PIN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
immunofluorescence
western blot
Anti-phospho-Pin1 (pSer16) antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse
Aplicação
western blot
Anti-PIN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunofluorescence
Anti-phospho-Pin1 (pSer16) antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
immunohistochemistry

western blot
Anti-Pin1 Antibody, clone 5B4.1, clone 5B4.1, from mouse,
Reatividade de espécies
human, rat
Aplicação
immunohistochemistry
western blot

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
Cicloheximida, from microbial, ≥94% (TLC),
Espécies
human
Cycloheximide solution, Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture,
Espécies
human
Cicloheximida, ≥90% (HPLC),
Espécies
human
Cicloheximida, Biotechnology Performance Certified,
Espécies
human
Cycloheximide solution, 0.1%, suitable for microbiology,
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human PIN1,
Espécies
human
MISSION® esiRNA, targeting mouse Pin1,
Espécies
mouse