14400

Biotine

≥99.0% (T)

• Synonyme(s) : D-Biotine, Bios II, Coenzyme R, Vitamine B7, Vitamine H
• Formule empirique (notation de Hill): C₁₀H₁₆N₂O₃S
• Numéro CAS: 58-85-5
• Poids moléculaire : 244.31
• Numéro Beilstein : 86838
• Numéro CE : 200-399-3
• Numéro MDL: MFCD00005541
• Code UNSPSC : 12352201
• eCl@ss : 34058011
• ID de substance PubChem : 329750287
• Nomenclature NACRES : NA.21

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Pureté: ≥99.0% (T)
• Forme: powder
• Activité optique: [α]20/D +91±2°, c = 1% in 0.1 M NaOH
• Résidus de calcination: ≤0.1% (as SO₄)
• Perte: ≤0.5% loss on drying
• Couleur: colorless to white
• Pf: 229-234 °C; 231-233 °C (lit.)
• Solubilité: alcohol: soluble 80mg/100 ml at 25 °C; water: soluble 22mg/100 ml at 25 °C; 0.1 M NaOH: 10 mg/mL at 25 °C, clear, colorless; H₂O: very soluble; organic solvents: insoluble
• Traces de cations: Ca: ≤50 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤10 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤500 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• Application(s): detection
• Chaîne SMILES: [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2
• InChI: 1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
• Clé InChI: YBJHBAHKTGYVGT-ZKWXMUAHSA-N

Description

Description générale

Biotin is readily available in several foods, like whole grains, nuts, legumes, unpolished rice and egg yolk. The normal gut flora also produces this vitamin.

Application

Biotin has been used for testing the functionality of the Avidin-displaying phages. The product has also been used for labeling the swine anti-rabbit IgG antibody and peroxidase.

Actions biochimiques/physiologiques

Biotin acts as an important cofactor for carboxylase enzymes in various metabolic pathways. Biotin favors keratin synthesis and hence is used as a supplement for hair and nail growth. Deficiency of biotin shows several symptoms such as alopecia, conjunctivitis, seborrheic dermatitis, depression, lethargy, hypotonia and seizures.

Biotin also referred to as vitamin H or vitamin B7 is a water-soluble B-vitamin that induces two to three fold increase in guanylate cyclase activity in rat liver, kidney, colon, cerebellum, and heart. It also stimulates the sperm motility and prolongs the survival of cryopreserved human spermatozoa.

Autres remarques

Reviews; Avidin-Biotin technology;

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)