539162

Proteasome Inhibitor II

The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyme(s) : Proteasome Inhibitor II, (Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
• Formule empirique (notation de Hill): C₂₉H₃₉N₃O₅
• Poids moléculaire : 509.64
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: lyophilized solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated
• Couleur: white
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; K_i = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
MPC

Product does not compete with ATP.

Reversible: yes

Target K_i: 460 nM against the pituitary multicatalytic proteinase complex (MPC)

Avertissement

Toxicity: Standard Handling (A)

Séquence

Z-Leu-Leu-Phe-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.

Autres remarques

Schauer, S.L., et al. 1998. J. Immunol. 160, 4398.
Orlowski, M., et al. 1997. Biochemistry 36, 13946.
Orlowski, M., et al. 1993. Biochemistry 32, 1563.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable