474780

MG-115

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

• Synonyme(s) : MG-115, Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII
• Formule empirique (notation de Hill): C₂₅H₃₉N₃O₅
• Numéro CAS: 133407-86-0
• Poids moléculaire : 461.59
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥90% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
• Clé InChI: QEJRGURBLQWEOU-FKBYEOEOSA-N

Description

Description générale

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
20S proteasome

Product does not compete with ATP.

Reversible: yes

Target K_i: 21 nM and 35 nM for 20S and 26S proteasome, respectively

Avertissement

Toxicity: Standard Handling (A)

Séquence

Z-Leu-Leu-Nva-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280.
Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
Vinitsky, A., et al. 1992. Biochemistry 31, 9421.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable