Direkt zum Inhalt
Merck

HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V

HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V application for HPLC

Materialien

Analytische Säule

Produkt-Nr.
Beschreibung
Preisangaben

11024AST

Astec® CHIROBIOTIC® V Chirale HPLC-Säule

5 μm particle size, L × I.D. 25 cm × 4.6 mm

Standard

Produkt-Nr.
Beschreibung
Preisangaben

S9944

Sibutramine -hydrochlorid Monohydrat

≥98% (HPLC), solid

CONDITIONS

column

CHIROBIOTIC V, 25 cm x 4.6 mm I.D., 5 μm particles (11024AST)

mobile phase

15 mM ammonium formate in methanol

flow rate

1 mL/min

column temp.

25 °C

detector

UV, 230 nm

injection

5 μL

sample

1 mg/mL in methanol

Beschreibung

Hinweis zur Analyse

Sibutramine, one of a few drugs approved for long-term treatment of obesity, is a chiral compound. The (R) enantiomer has the desired effect of reducing body weight and food intake, but the (S) enantiomer has the opposite effect: A perfect example of why chiral HPLC is important to pharmaceutical and clinical analysts. Astec® CHIROBIOTIC® V successfully separates sibutramine enantiomers, using a simple, MS-friendly mobile phase.

Rechtliche Hinweise

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

Chromatogram Search

Related Product Categories

HPLC ColumnsGC Columns & AccessoriesTLC Plates & AdsorbentsSolid Phase Microextraction (SPME)Solid Phase Extraction & QuEChERS

Related Applications

Small Molecule HPLCLarge Molecule HPLCGas Chromatography (GC)TLCSolid Phase Microextraction (SPME)Solid Phase Extraction (SPE)QuEChERS