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S9944

Sigma-Aldrich

Sibutramine -hydrochlorid Monohydrat

≥98% (HPLC), solid

Synonym(e):

1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine -hydrochlorid Monohydrat, Meridia, Reductil

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About This Item

Empirische Formel (Hill-System):
C17H26ClN · HCl
CAS-Nummer:
84485-00-7
Molekulargewicht:
316.31
MDL-Nummer:
MFCD04039806
UNSPSC-Code:
12352116
PubChem Substanz-ID:
329824638
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Arzneimittelkontrolle

USDEA Schedule IV

Lagerbedingungen

desiccated

Farbe

white

Löslichkeit

DMSO: >30 mg/mL
H2O: insoluble

Ersteller

Abbott

Lagertemp.

room temp

SMILES String

O.Cl.CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2

InChI

1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2

InChIKey

KFNNPQDSPLWLCX-UHFFFAOYSA-N

Angaben zum Gen

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

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Anwendung

Sibutramine hydrochloride monohydrate was used as standard to screen dietary supplements for sibutramine using ion mobility spectrometer.1

Biochem./physiol. Wirkung

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

Leistungsmerkmale und Vorteile

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Jamie D Dunn et al.
Journal of pharmaceutical and biomedical analysis, 54(3), 469-474 (2010-10-14)
In response to recent incidents of undeclared sibutramine, an appetite suppressant found in dietary supplements, we developed a method to detect sibutramine using hand-held ion mobility spectrometers with an analysis time of 15 s. Ion mobility spectrometry is a high-throughput
Cibele S Borges et al.
PloS one, 8(6), e66091-e66091 (2013-06-19)
Sperm acquire motility and fertility capacity during epididymal transit, under the control of androgens and sympathetic innervations. It is already known that the acceleration of epididymal sperm transit time can lead to lower sperm quality. In a previous work we
Hiroaki Yashiro et al.
PloS one, 11(11), e0166198-e0166198 (2016-11-11)
Obesity is now recognized as a state of chronic low-grade inflammation and is called as metabolic inflammation. Delta-5 desaturase (D5D) is an enzyme that metabolizes dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA). Thus, D5D inhibition increases DGLA (precursor to anti-inflammatory
Alexandre V Ivachtchenko et al.
Journal of Alzheimer's disease : JAD, 58(4), 1043-1063 (2017-05-28)
Discovery of 5-HT6 receptor subtype and its exclusive localization within the central nervous system led to extensive investigations of its role in Alzheimer's disease, schizophrenia, and obesity. In the present study, we present preclinical evaluation of a novel highly-potent and
Cristiani F Bortolatto et al.
Psychopharmacology, 232(13), 2239-2249 (2015-01-08)
The searching for safe and effective antiobesity drugs has been the subject of intense research. Previous studies have shown several pharmacological applications of organoselenium compounds; however, their possible anorectic-like actions have not been investigated. This study aims to investigate the
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