T9283

Monoclonal Anti-Tropomyosin (Sarcomeric) antibody produced in mouse

clone CH1, ascites fluid

• Synonym(e): Anti-C15orf13, Anti-CMD1Y, Anti-CMH3, Anti-HEL-S-265, Anti-HTM-alpha, Anti-LVNC9, Anti-TMSA
• MDL-Nummer: MFCD00149029
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: ascites fluid
• Antikörper-Produkttyp: primary antibodies
• Klon: CH1, monoclonal
• Enthält: 15 mM sodium azide
• Speziesreaktivität: human, chicken, rat
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50 using sections of human tongue; immunohistochemistry (frozen sections): suitable using human and animal tissue sections; immunoprecipitation (IP): suitable; microarray: suitable; western blot: suitable using native preparations
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: P09493
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: chicken ... TPM1(396366) ; human ... TPM1(7168) ; rat ... Tpm1(24851)

Beschreibung

Allgemeine Beschreibung

Tropomyosin 1 (TPM1) is encoded by the gene mapped to human chromosome 15q22.2. The encoded protein belongs to the TPM protein family.

Spezifität

The antibody recognizes an epitope on skeletal and cardiac tropomyosin. The antibody shows no reaction with denatured protein by immunoblotting. No cross-reactivity has been observed with smooth muscle or non-muscle tropomyosin.

Immunogen

chicken muscle tropomyosin.

Anwendung

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Monoclonal Anti-Tropomyosin (sarcomeric) antibody produced in mouse has been used in immunofluorescence and immunohistochemistry.

Biochem./physiol. Wirkung

Tropomyosin 1 (TPM1) is a potent tumor suppressor gene. It is expressed at low levels in various types of solid cancers including, oral squamous cell carcinoma (OSCC) and tongue squamous cell carcinoma. Mutation in the gene is associated with the development of hypertrophic cardiomyopathy. The encoded protein is involved in the regulation of actin-myosin interaction in striated muscles. Tropomyosin plays an essential role in Ca²⁺ -regulated contraction of cardiac muscle.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable