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Merck
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Dokumente

T6069

Sigma-Aldrich

Thio-TEPA

Synonym(e):

N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide

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About This Item

Empirische Formel (Hill-System):
C6H12N3PS
CAS-Nummer:
52-24-4
Molekulargewicht:
189.22
EG-Nummer:
200-135-7
MDL-Nummer:
MFCD00145452
UNSPSC-Code:
51102829
PubChem Substanz-ID:
24900346
NACRES:
NA.85

Form

solid

Lagerbedingungen

(Keep container tightly closed in a dry and well-ventilated place.)

Farbe

white

Wirkungsspektrum von Antibiotika

neoplastics

Wirkungsweise

DNA synthesis | interferes

Lagertemp.

2-8°C

SMILES String

S=P(N1CC1)(N2CC2)N3CC3

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

InChIKey

FOCVUCIESVLUNU-UHFFFAOYSA-N

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Verwandte Kategorien

Allgemeine Beschreibung

Chemical structure: aziridine

Anwendung

A polyfunctional alkylating agent

Biochem./physiol. Wirkung

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.

Hinweis zur Analyse

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

H-Sätze

H300,H350

Gefahreneinstufungen

Acute Tox. 2 Oral - Carc. 1B

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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