Alle Fotos(2)
Wichtige Dokumente
T1408
holo-Transferrin Rind
Synonym(e):
Siderophilin, Siderophilin, eisengesättigt
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(2)
About This Item
Empfohlene Produkte
Biologische Quelle
bovine
Qualitätsniveau
Assay
97-100% (agarose gel electrophoresis)
Form
powder
Methode(n)
cell culture | mammalian: suitable
UniProt-Hinterlegungsnummer
Lagertemp.
2-8°C
Angaben zum Gen
bovine ... TF(280705)
Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich
Allgemeine Beschreibung
Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.
Anwendung
Holo-Transferrin bovine has been used:
- as a RPMI-1640 medium supplement for culturing cancer cell lines
- as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture
- to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis
- as a standard for strong anion exchange (SAX) reactor measurements
Biochem./physiol. Wirkung
Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.
Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.
Hinweis zur Analyse
Reinheit mittels Agarose-Gelelektrophorese
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Kunden haben sich ebenfalls angesehen
Bovine and canine transferrin inhibit the growth of Malassezia pachydermatis in vitro
Bond R, et al.
Medical Mycology, 43(5), 447-451 (2005)
N P Singh et al.
Life sciences, 70(1), 49-56 (2002-01-05)
Artemisinin becomes cytotoxic in the presence of ferrous iron. Since iron influx is high in cancer cells, artemisinin and its analogs selectively kill cancer cells under conditions that increase intracellular iron concentrations. We report here that after incubation with holotransferrin
New ammunition for the proteomic reactor: strong anion exchange beads and multiple enzymes enhance protein identification and sequence coverage
Zhou H, et al.
Analytical and Bioanalytical Chemistry, 397(8), 3421-3430 (2010)
Dynamics of iron release from transferrin N-lobe studied by electrospray ionization mass spectrometry
Gumerov DR and Kaltashov IA
Analytical Chemistry, 73(11), 2565-2570 (2001)
A single nucleotide polymorphism in the coding region of bovine transferrin is associated with milk fat yield
Sanz A, et al.
Genetics and molecular research : GMR, 9(2), 843-848 (2010)
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
Setzen Sie sich mit dem technischen Dienst in Verbindung.