T0397

L-Thyroxin Natriumsalz Pentahydrat

γ-irradiated, powder, BioXtra, suitable for cell culture

• Synonym(e): 3-[4-(4-Hydroxy-3,5-diiodphenoxy)-3,5-diiodphenyl]-L-alanin Natriumsalz, Natrium-levothyroxin, T₄
• Lineare Formel: HOC₆H₂I₂OC₆H₂I₂CH₂CH(NH₂)COONa · 5H₂O
• CAS-Nummer: 6106-07-6
• Molekulargewicht: 888.93
• Beilstein: 5721845
• EG-Nummer: 200-221-4
• MDL-Nummer: MFCD00149110
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24899887
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Sterilität: γ-irradiated
• Produktlinie: BioXtra
• Assay: ≥98%
• Form: powder
• Wirksamkeit: 5-50 ng/mL
• Methode(n): cell culture | mammalian: suitable
• mp (Schmelzpunkt): 207-210 (dec.) (lit.)
• Löslichkeit: cell culture medium: 0.1 mg/mL; H₂O: soluble
• Lagertemp.: −20°C
• SMILES String: O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1
• InChIKey: JMHCCAYJTTWMCX-QWPJCUCISA-M
• Angaben zum Gen: mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

Beschreibung

Biochem./physiol. Wirkung

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Physikalische Form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Rekonstituierung

To prepare 20 μg/ml stock solution, add 50 ml sterile culture medium.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H372
• P-Sätze: P260 - P264 - P270 - P314 - P501
• Gefahreneinstufungen: STOT RE 1
• Zielorgane: Thyroid,Cardio-vascular system,Kidney
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)