SRP6182
Human Serum Albumin
≥98% (SDS-PAGE)
Synonym(e):
GIG20, GIG42, HSA, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341, serum albumin
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About This Item
UNSPSC-Code:
12352202
NACRES:
NA.32
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Allgemeine Beschreibung
The gene HSA (human serum albumin) is mapped to human chromosome 4q13.3. The gene encodes a protein of 585 amino acids with a molecular weight of 66.4kDa. HSA is the most abundant protein in the plasma and has many metal-binding sites.
Anwendung
HSA (human serum albumin) has been used for the development of automated dye-binding method for serum albumin determination using bromcresol purple. It has also been used to study effect of HSA on DNA transfection by lipoplexes.
Biochem./physiol. Wirkung
HSA (human serum albumin) mainly works as a carrier for various nutrients, metabolites and xenobiotics. It interacts with plasma zinc and regulates uptake of zinc in cells. HSA plays a crucial role in drug pharmacokinetics. It also controls oncotic pressure and volume of the blood. Mutations in the gene are linked with congenital analbuminemia and familial dysalbuminemic hyperthyroxinemia.
Physikalische Form
Sterile filtered yellowish liquid.
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Human serum albumin enhances DNA transfection by lipoplexes and confers resistance to inhibition by serum.
Sim?es S
Biochimica et Biophysica Acta, 1463, 459-469 (2000)
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families.
Sunthornthepvarakul T
Biochemical and Biophysical Research Communications, 202, 781-787 (1994)
A nucleotide insertion and frameshift cause analbuminemia in an Italian family.
Watkins S
Proceedings of the National Academy of Sciences of the USA, 91, 2275-2279 (1994)
A nucleotide deletion and frame-shift cause analbuminemia in a Turkish family.
Caridi G
Biochemia Medica, 26, 264-271 (2016)
Structure and ligand binding properties of human serum albumin.
Kragh-Hansen U
Danish Medical Bulletin, 37, 57-84 (1990)
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