SML1822

Akebiasaponin D

≥98% (HPLC)

• Synonym(e): Leiyemudanosid A, Taurosid St-G0-1
• Empirische Formel (Hill-System): C₄₇H₇₆O₁₈
• CAS-Nummer: 39524-08-8
• Molekulargewicht: 929.10
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: (Dipsacus asper)
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +13 to +18°, c = 0.5 in methanol
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 3 mg/mL, clear (warmed)
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: CC1(C)CC[C@]2(C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)CC[C@@]5(C)[C@]6(C)CCC7[C@](C)(CO)[C@@H](O[C@]8([H])OC[C@H](O)[C@H](O)[C@H]8O)CC[C@]7(C)[C@@]6([H])CC=C5[C@]2([H])C1
• InChI: 1S/C47H76O18/c1-42(2)13-15-47(41(59)65-40-37(58)34(55)32(53)26(63-40)20-61-38-36(57)33(54)31(52)25(18-48)62-38)16-14-45(5)22(23(47)17-42)7-8-28-43(3)11-10-29(64-39-35(56)30(51)24(50)19-60-39)44(4,21-49)27(43)9-12-46(28,45)6/h7,23-40,48-58H,8-21H2,1-6H3/t23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+,39-,40-,43-,44-,45+,46+,47-/m0/s1
• InChIKey: CCRXMHCQWYVXTE-HMRSNRLKSA-N

Beschreibung

Biochem./physiol. Wirkung

Akebia saponin D (ASD) is a bioactive triterpenoid saponin isolated from the rhizome of Dipsacus asper Wall that is used as an anti-osteoporosis drug. Akebia saponin D exhibits therapeutic effects in number of disease models including cancer, Alzheimer′s disease, cardiovascular disease, and bone fractures. Akebia saponin D protects against nonalcoholic fatty liver disease (NAFLD) liver damage in mice model of NAFLD. ASD decreases hepatic steatosis and heptocyte apoptosis through autophagy modulation. Akebia saponin D prevents oleic acid induced lipid droplets accumulation and increases autophagic flux BRL cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable