SCP0094

Caspase Inhibitor

• Synonym(e): Ac-AEVD-CHO, caspase 6 inhibitor, caspase 8 inhibitor
• Empirische Formel (Hill-System): C₁₉H₃₀N₄O₉
• Molekulargewicht: 458.46
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: lyophilized
• Zusammensetzung: Peptide Content, ≥80%
• Lagerbedingungen: protect from light
• Lagertemp.: −20°C
• Angaben zum Gen: human ... CASP10(843) , CASP6(839) , CASP8(841) , CASP9(842)

Beschreibung

Amino Acid Sequence

Ac-Ala-Glu-Val-Asp-al

Allgemeine Beschreibung

Currently, there are 13 caspases recognized in mammals. Caspases are classified as initiators and effectors. Caspase 8 belongs to the class of initiators. It possesses a prodomain at the terminal and contains the death effector domain which serves as protein-protein interaction motif for caspase 8. With respect to substrate specificity, caspase 8 is classified as a member of group III. It specifically recognizes the (I/L/V) EXD sequence on the substrate.

Anwendung

Caspase Inhibitor has been used to study the specificity of the CIL-1 (desglucoanagalloside B) interaction with the caspase 3/7 system.

Biochem./physiol. Wirkung

The peptide Ac-Ala-Glu-Val-Asp-al, or Ac-AEVD-CHO, is an inhibitor of Group III caspases. It acts upon caspases-6, 8, 9, and 10, with particular effectiveness on caspase-6 and caspase-8. The use of Ac-AEVD-CHO in several apotosis studies has been reported.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable