SAB4700262

Monoclonal Anti-CD105 antibody produced in mouse

clone MEM-229, purified immunoglobulin, buffered aqueous solution

• Synonym(e): Anti-ENG, Anti-Endoglin
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: MEM-229, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human, pig
• Konzentration: 1 mg/mL
• Methode(n): flow cytometry: suitable
• Isotyp: IgG2a
• NCBI-Hinterlegungsnummer: NM_000118.2
• UniProt-Hinterlegungsnummer: P17813
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ENG(2022)

Beschreibung

Allgemeine Beschreibung

CD105, also known as endoglin (ENG) gene is mapped to human chromosome 9q34.11. The gene codes for a homodimeric transmembrane coreceptor containing disulfide-linked subunits of 95kDa. The encoded protein is mainly expressed on human pre-erythroblasts, macrophages, leukemic cells of the lymphoid and myeloid lineages. It is also present at higher levels on syncytiotrophoblasts of term placenta and vascular endothelial cells.

The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Immunogen

Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA

Anwendung

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)

Biochem./physiol. Wirkung

CD105/ endoglin (ENG) acts as an accessory receptor within transforming growth factor (TGF)-β signalling pathway. It is implicated in the regulation of TGF-β-dependent cellular responses. The protein expressed in endothelial cells plays a vital role in angiogenesis and tumour progression. CD105 functions as a potential target of epigenetic silencing in lung cancer. Deletion of the gene leads to hereditary hemorrhagic telangiectasia. In addition, mutations in the gene is also associated with various cardiovascular anomalies and different types of cancers.

Leistungsmerkmale und Vorteile

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Physikalische Form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable