SAB4503212

Anti-Collagen α1 XVIII, C-Terminal antibody produced in rabbit

affinity isolated antibody

• Synonym(e): COIA1, Collagen α-1(XVIII) chain, Endostatin
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 153 kDa
• Speziesreaktivität: human, mouse
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:20000; immunohistochemistry: 1:50-1:100
• NCBI-Hinterlegungsnummer: P39060
• UniProt-Hinterlegungsnummer: P39060
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... COL18A1(80781)

Beschreibung

Allgemeine Beschreibung

Endostatin is a naturally occurring 20kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. The gene encoding it is localized on human chromosome 21q22.3. Anti-Collagen α1 XVIII Antibody detects endogenous levels of total Collagen α1 XVIII protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen alpha1 XVIII.

Immunogen Range: 1301-1350

Biochem./physiol. Wirkung

Endostatin inhibits the proliferation and migration of endothelial cells. It blocks apoptosis of cells and G1 to S phase transition in the cell cycle. It inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Mutations in this gene lead to Knobloch Syndrome (KS), a rare autosomal recessive disorder.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable