SAB4501599

Anti-JAK2 antibody produced in rabbit

affinity isolated antibody

• Synonym(e): JAK-2, JAK2, Janus kinase 2, kinase Jak2
• MDL-Nummer: MFCD00802820
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 130 kDa
• Speziesreaktivität: mouse, rat, human
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:5000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: O60674
• UniProt-Hinterlegungsnummer: O60674
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... JAK2(3717)

Beschreibung

Allgemeine Beschreibung

Anti-JAK2 antibody detects endogenous levels of total JAK2 protein.

JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the the Jak family of proteins. It is located on human chromosome 9p24.

Immunogen

The antiserum was produced against synthesized peptide derived from human JAK2.

Immunogen Range: 541-590

Biochem./physiol. Wirkung

JAK2 (janus kinase 2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable