SAB4200096

Anti-Coronin 1B antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• Synonym(e): Anti-CORO1B, Anti-Coronin-2
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~66 kDa
• Speziesreaktivität: mouse, rat, human
• Verpackung: antibody small pack of 25 μL
• Konzentration: ~1.5 mg/mL
• Methode(n): indirect immunofluorescence: 5-10 μg/mL using HS68 cells; western blot: 1.5-3.0 μg/mL using PC12 cell extracts and mouse brain extracts (S1 fraction)
• UniProt-Hinterlegungsnummer: Q9BR76
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CORO1B(57175)

Beschreibung

Allgemeine Beschreibung

Coronin 1B (CORO1B) is encoded by the gene mapped to human chromosome 11q13.2. CORO1B belongs to the mammalian coronin gene family. The encoded protein is ubiquitously expressed and is mainly present on the leading edge of migrating fibroblasts.

Coronin-1B localizes to sub-membrane areas.

Anwendung

Anti-Coronin 1B antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem./physiol. Wirkung

Coronin 1B (CORO1B) acts as an actin binding protein. It also plays a major role in controlling whole-cell motility and lamellipodial dynamics. CORO1B also influence neurite outgrowth in a neuronal regeneration model. The encoded protein antagonizes a filament branch stabilizer, cortactin and disassembles actin-related protein (Arp) 2/3-containing actin filament branches by promoting Arp2/3 dissociation.

Coronin-1B has been shown to affect cell motility by regulation of actin-depolymerizing factor (ADF)/cofilin proteins at the leading edge. It targets the cofilin-activating phosphatase slingshot-1L to the leading edge, and thus indirectly regulates cofilin activity.

Physikalische Form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable