S9311

SIB 1893

>99%, solid

• Synonym(e): [E]-2-Methyl-6-[2-phenylethenyl]pyridine
• Empirische Formel (Hill-System): C₁₄H₁₃N
• CAS-Nummer: 7370-21-0
• Molekulargewicht: 195.26
• MDL-Nummer: MFCD02262120
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278718
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: >99%
• Form: solid
• Löslichkeit: DMSO: 18 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cc1cccc(\C=C\c2ccccc2)n1
• InChI: 1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
• InChIKey: SISOFUCTXZKSOQ-ZHACJKMWSA-N
• Angaben zum Gen: human ... GRM1(2911) , GRM5(2915)

Beschreibung

Anwendung

SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.

Biochem./physiol. Wirkung

SIB 1893 non-competitively inhibits glutamate-induced increase in Ca²⁺ at human metabotropic glutamate receptor 1 (hmGluR1).¹ It also acts as a positive allosteric modulator of hmGluR4.²

Selective and noncompetitive mGlu₅ metabotropic glutamate receptor antagonist.

Leistungsmerkmale und Vorteile

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315 - H319 - H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves