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P2795

Sigma-Aldrich

Phytosphingosine hydrochloride

greener alternative

Synonym(e):

4-Hydroxysphinganine, PHS

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About This Item

Empirische Formel (Hill-System):
C18H39NO3 · HCl
CAS-Nummer:
554-62-1
Molekulargewicht:
353.97
MDL-Nummer:
MFCD06804643
UNSPSC-Code:
12352211
PubChem Substanz-ID:
24898363
NACRES:
NA.25

Form

powder

Qualitätsniveau

200

Grünere Alternativprodukt-Bewertung

old score: 19
new score: 9
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Grünere Alternativprodukt-Eigenschaften

Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

Grünere Alternativprodukt-Kategorie

, Re-engineered

Lipid-Typ

sphingolipids

Lagertemp.

−20°C

SMILES String

Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO

InChI

1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1

InChIKey

GDKAAHDFPOWGQE-RXQQAGQTSA-N

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Biochem./physiol. Wirkung

Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨm and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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International journal of pharmaceutics, 393(1-2), 152-160 (2010-05-04)
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