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Merck

O7125

Sigma-Aldrich

L-Ornithin -L-aspartat (Salz)

≥98% (TLC)

Synonym(e):

(S)-2,5-Diaminopentanoic acid L-aspartate salt

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About This Item

Empirische Formel (Hill-System):
C9H19N3O6
CAS-Nummer:
Molekulargewicht:
265.26
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352209
PubChem Substanz-ID:
NACRES:
NA.26

product name

L-Ornithin -L-aspartat (Salz), powder

Assay

≥98% (TLC)

Form

powder

Farbe

white to off-white

Lagertemp.

2-8°C

SMILES String

NCCC[C@H](N)C(O)=O.N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C5H12N2O2.C4H7NO4/c6-3-1-2-4(7)5(8)9;5-2(4(8)9)1-3(6)7/h4H,1-3,6-7H2,(H,8,9);2H,1,5H2,(H,6,7)(H,8,9)/t4-;2-/m00/s1

InChIKey

IXUZXIMQZIMPSQ-ZBRNBAAYSA-N

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Biochem./physiol. Wirkung

L-Ornithine L-aspartate is a metabolite of arginine degradation by arginase. It has been shown to reduce blood ammonia concentrations by increasing ammoniadetoxification in the muscle and reducing the severity of hepatic encephalopathy in cirrhosis.

Sonstige Hinweise

Product of arginine degradation by arginase

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Fulminate liver insufficiency can have many causes and is a challenge for differential diagnosis. A 39-year-old woman was admitted because of a nonitching macular-papular exanthema on both thighs with spreading to the trunk. In addition, the patient complained of dysphagia
Gavin Wright et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(2), 163-175 (2010-08-03)
Hepatic encephalopathy complicates the course of both acute and chronic liver disease and its treatment remains an unmet clinical need. Ammonia is thought to be central in its pathogenesis and remains an important target of current and future therapeutic approaches.
B M Datsenko et al.
Klinichna khirurhiia, (4)(4), 9-12 (2013-07-31)
Comparative analysis of results of examination and treatment of 54 patients, suffering obturation jaundice syndrome, is presented. The presence and severity of hepatic dysfunction was determined in accordance to indices of cytolysis and cholestasis syndromes, and its severity--in accordance to
Suzanna Ndraha et al.
Acta medica Indonesiana, 42(3), 158-161 (2010-08-21)
Excessive protein intake can cause hepatic encephalopathy (HE). Restricting protein in HE is becoming a controversy, because it can worsen malnutrition. This article reports the case of an under nourishment HE which is treated with L-ornithine-L-aspartate (LOLA) and given appropriate
Treatment of hyperammonemia in liver failure: a tale of two enzymes.
Rajiv Jalan et al.
Gastroenterology, 136(7), 2048-2051 (2009-05-05)

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