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M5319
Matrin
Synonym(e):
Matridin-15-one, Sophocarpidine
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About This Item
Empirische Formel (Hill-System):
C15H24N2O
CAS-Nummer:
Molekulargewicht:
248.36
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.25
Empfohlene Produkte
Qualitätsniveau
Anwendung(en)
metabolomics
vitamins, nutraceuticals, and natural products
Lagertemp.
2-8°C
SMILES String
O=C1CCCC2C3CCCN4CCCC(CN12)C34
InChI
1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1
InChIKey
ZSBXGIUJOOQZMP-JLNYLFASSA-N
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Allgemeine Beschreibung
Matrine (MT) or Sophocarpidine is a naturally occurring bioactive compound, extracted from traditional Chinese herbs like Sophora flavescens and Radix Sophorae tonkinensis.
Anwendung
Matrine has been used:
- to study its antioxidant and protective effect on doxorubicin (DOX)-induced cardiotoxicity in mice model and H9C2 cells
- as a chemotherapeutic agent to test its inhibitory effect on the growth of human glioblastoma multiforme (GBM) cells, and ovarian cancer cells
- to study its effect on mitochondrial fission and its anti-tumor functionality in HepG2 cells
- as a necroptosis inducer in cholangiocarcinoma (CCA) cell lines
Biochem./physiol. Wirkung
Matrine is a potent therapeutic agent with various pharmacological like anti-cancer, anti-bacterial, anti-fibrotic, anti-inflammatory properties. It is a macropinocytosis inducer and decreases the cellular adenosine triphosphate (ATP) level. Matrine may also serve as an effective sedative agent. It serves as an anti-inflammatory agent in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced intestinal inflammation in mice. It functions to reverse the Warburg effect and suppress the growth of human colon cancer cells.
Matrine is an alkaloid that is one of the major components in the root of the saphoro plant. Matrine has been studied for possible antiviral efficacy against hepatitis B and C, as well as impact against some skin diseases and forms of cancer.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Xiao-Yan Liu et al.
International journal of dermatology, 47(5), 448-456 (2008-04-17)
Matrine is a traditional Chinese medicine with significant inhibitory activity against malignant tumors. Its effects on the invasiveness and metastasis of malignant tumors have rarely been reported. To investigate whether matrine can inhibit the metastasis-related activities of the human malignant
Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression.
Zhang Y, Dong Z, Jin L, et al.
Biochemical Pharmacology (2012)
Peiyuan Li et al.
Frontiers in physiology, 10, 28-28 (2019-02-26)
This study mainly investigated the effect of matrine on TNBS-induced intestinal inflammation in mice. TNBS treatment caused colonic injury and gut inflammation. Matrine (1, 5, and 10 mg/kg) treatment alleviated colonic injury and gut inflammation via reducing bleeding and diarrhea
Wenjing Zhou et al.
Cancer medicine, 7(9), 4729-4743 (2018-08-07)
Matrine, a traditional Chinese medicine, has recently been shown to have antitumor properties in diverse cancer cells. Here, we explored the effect of matrine on human glioblastoma multiforme (GBM) cells. Glioblastoma multiforme cell lines were treated with matrine to assess
Lei Guo et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 14(10), 780-784 (2012-10-25)
To investigate the effects of matrine on the proliferation and apoptosis of human rhabdomyosarcoma RD cells in vitro, and to explore the mechanism of matrine inducing apoptosis of RD cells. MTT assay was used to measure the proliferation inhibition rates
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