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M3445

Sigma-Aldrich

Magnolol

≥90% (HPLC), from plant

Synonym(e):

2,2′-Bichavicol, 5,5′-Diallyl-2,2′-biphenyldiol

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About This Item

Empirische Formel (Hill-System):
C18H18O2
CAS-Nummer:
528-43-8
Molekulargewicht:
266.33
MDL-Nummer:
MFCD00016658
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24896843
NACRES:
NA.25

Biologische Quelle

plant

Qualitätsniveau

200

Assay

≥90% (HPLC)

Löslichkeit

ethanol: soluble 1 mg/mL
methanol: soluble 1.5 mg/mL

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria
fungi

Anwendung(en)

metabolomics
vitamins, nutraceuticals, and natural products

Wirkungsweise

cell membrane | interferes

Lagertemp.

2-8°C

SMILES String

Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

InChIKey

VVOAZFWZEDHOOU-UHFFFAOYSA-N

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Verwandte Kategorien

Allgemeine Beschreibung

Magnolol is a bioactive neolignan extracted from the root and stem bark of different Chinese herbal Magnolia trees. It has a hydroxylated bi-phenoid structure like that of its structural isomer honokiol. It is a lipophilic compound.

Anwendung

Magnolol has been used:
  • to test its effect on muscle atrophy and macrophage subtypes in sarcopenia mouse model
  • to test its inhibitory effect on human umbilical vein endothelial cells (HUVECs) in angiogenesis assay
  • to test its anti-fungal effects on growth, ultrastructure, and biofilm formation of Candida spp. strains
  • in the preparation of immobilized amino-functionalized mesoporous silica particles for prolonged-release studies

Biochem./physiol. Wirkung

Magnolol exerts anti-depressant and, neurodegenerative properties. It is also considered to be a potent anti-cancer agent for its involvement in reducing cell proliferation, cell cytotoxicity, and inducing apoptosis.
Magnolol is a bioactive plant component isolated from the root and stem bark of Magnolia officinalis with antifungal, antibacterial and antioxidant effects. Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling. It also appears to have anti-inflammatory properties related to vascular disorders such as atherosclerosis due to its ability to inhibit IL-6-induced STAT3 activation.

Signalwort

Danger

Gefahreneinstufungen

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Rajendra Karki et al.
Experimental cell research, 319(20), 3238-3250 (2013-08-03)
Increased proliferation and migration of vascular smooth muscle cells (VSMCs) contribute importantly to the formation of both atherosclerotic and restenotic lesions. The objective of this study was to investigate the effect of magnolol on VSMC migration. The proteolytic activity of
Abhishek Manoj Ranaware et al.
International journal of molecular sciences, 19(8) (2018-08-15)
The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will
Hanna Kuk et al.
Scientific reports, 7(1), 17820-17820 (2017-12-21)
Due to gravity the venous vasculature in the lower extremities is exposed to elevated pressure levels which may be amplified by obesity or pregnancy. As a consequence, venules dilate and may be slowly transformed into varicose or spider veins. In
Development of a prolonged-release drug delivery system with magnolol loaded in amino-functionalized mesoporous silica
Stefanache A, et al.,
Applied Sciences, 237-237 (2017)
Yong Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(23), 3526-3530 (2013-03-13)
Magnolol is one of main active constituents from Magnolia officinalis, a widely used traditional Chinese medicine. Previous studies have proved its multiple pharmacological effects, such as anti-oxidation, anti-microbial and anti-tumor. In recent years, more and more studies have focused on
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