L7757

Lidocain

≥98% (GC), powder, neuroprotective agent

• Synonym(e): 2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamid, Lignocain, Xylocain
• Empirische Formel (Hill-System): C₁₄H₂₂N₂O
• CAS-Nummer: 137-58-6
• Molekulargewicht: 234.34
• EG-Nummer: 205-302-8
• MDL-Nummer: MFCD00026733
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24896480
• NACRES: NA.77

Eigenschaften

• product name: Lidocain, powder
• Form: powder
• SMILES String: CCN(CC)CC(=O)Nc1c(C)cccc1C
• InChI: 1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
• InChIKey: NNJVILVZKWQKPM-UHFFFAOYSA-N
• Angaben zum Gen: human ... CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Scnn1a(25122)

Beschreibung

Allgemeine Beschreibung

Lidocaine is a local anesthetic and an effective antiarrhythmia agent. It occurs as solutions of crystalline colorless solid for injections, that has a short half-life within plasma.

Anwendung

Lidocaine may be used for drug testing and for voltage clamp experiments.

Biochem./physiol. Wirkung

Na⁺ Kanalblocker; Klasse IB Antiarrhythmikum.

Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na⁺) channels. It prevents the influx of sodium ions leading to depolarization of sodium channels and metabolically inactivated in liver. Lidocaine has positive effect on cerebral ischemia. It is also used in the treatment of ventricular tachycardia. Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves