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EPS002

Sigma-Aldrich

MS-275

A HDAC1 and HDAC3 inhibitor

Synonym(e):

MS-275 (Entinostat, SNDX-275), 3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate, N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide

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About This Item

Empirische Formel (Hill-System):
C21H20N4O3
CAS-Nummer:
209783-80-2
Molekulargewicht:
376.41
MDL-Nummer:
MFCD03453552
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329799578
NACRES:
NA.41

Assay

≥99%

Löslichkeit

DMSO: 38 mg/mL

Lagertemp.

−20°C

SMILES String

Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2

InChI

1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

InChIKey

INVTYAOGFAGBOE-UHFFFAOYSA-N

Angaben zum Gen

human ... HDAC1(3065) , HDAC10(83933) , HDAC11(79885) , HDAC2(3066) , HDAC3(8841) , HDAC4(9759) , HDAC5(10014) , HDAC6(10013) , HDAC7(51564) , HDAC8(55869) , HDAC9(9734)

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Allgemeine Beschreibung

Preferentially inhibits HDAC1 (IC50=300 nM) over HDAC3 (IC50=8 μM). Has no inhibitory activity towards HDAC8 (IC50>100 μM).

Anwendung

MS-275 has been used as a histone deacetylase-1 inhibitor.

Biochem./physiol. Wirkung

HDAC inhibitor; antiproliferative.

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

H-Sätze

H301,H360

Gefahreneinstufungen

Acute Tox. 3 Oral - Repr. 1A

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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