C1538

Complement C8 deficient serum human

for complement assays

• UNSPSC-Code: 12352202
• NACRES: NA.61

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Form: solution
• Ursprung: USA origin
• Methode(n): activity assay: suitable
• Verunreinigungen: infectious agent, tested
• UniProt-Hinterlegungsnummer: P07357
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... C8A(731)

Beschreibung

Anwendung

Complement C8 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C8 may result in an increased susceptibility to Neisseria meningitidis. The most common mutation resulting in a C8 deficiency is a C to T transition in exon 9 of the C8 beta gene. Recent research however, has also discovered that two separate heterogeneous mutations may result in C8 deficiency in patients displaying recurrent meningococcal meningitis. These mutations are a duplication mutation on exon 7 and a mutation on exon 3.

Biochem./physiol. Wirkung

Serum naturally deficient in C8 may actually contain some C8, though in greatly reduced quantity. Terminal complement complex is present at trace levels in such sera.

Physikalische Form

Supplied as a solution in PBS, pH 7.3

Hinweis zur Analyse

C8 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable