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Merck

A3418

Sigma-Aldrich

Anti-α1-Acid Glycoprotein antibody produced in goat

whole antiserum

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

goat

Konjugat

unconjugated

Antikörperform

whole antiserum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Mol-Gew.

antigen 40.8 kDa (sedimentation velocity and diffusion studies)

Enthält

15 mM sodium azide

Speziesreaktivität

human

Methode(n)

quantitative precipitin assay: 1.5 mg/mL

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... ORM1(5004)

Allgemeine Beschreibung

α-1 acid glycoprotein is a protein at 43kDa secreted mainly from the liver during acute phase reaction. Its expression is induced by cytokines and corticosteroids.
Alpha-1-acid glycoprotein (AGP) is also known as orosomucoid (ORM). It is a 41-43 kDa glycoprotein. It is one of the important acute phase proteins found in humans, rats, mice and other species. This immunosuppressive glycoprotein is composed of two isoforms, such as ORM1 and ORM2.
Goat Anti-α1-Acid Glycoprotein antibody is immunospecific for human α1-acid glycoprotein by immunoelectrophoresis versus human serum and α1-acid glycoprotein.

Immunogen

purified human α1-acid glycoprotein

Anwendung

Goat Anti-α1-Acid Glycoprotein antibody can be used for quantitative precipitin assays at 1.5mg/ml.

Biochem./physiol. Wirkung

Abberations of orosomucoid 1 (ORM1) is linked with the pharmacokinetics of telmisartan. This plasma protein participates in the binding and transport of several drugs.

Physikalische Form

Supplied as a liquid containing 15mM sodium azide as preservative.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

P-Sätze

Gefahreneinstufungen

Acute Tox. 4 Dermal - Aquatic Chronic 3

Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 3


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics
Huang Z, et al.
Current Drug Metabolism, 14(2), 226-238 (2013)
P A Charlwood et al.
Biochimica et biophysica acta, 453(1), 81-92 (1976-11-26)
We have isolated from the plasma of man, rabbit, pig, rat and chicken alpha 1-acid glycoproteins that show a single band on polyacrylamide gel electrophoresis and a single arc in immunodiffusion. Amino acid and carbohydrate compositions are presented. The human
K Kostner et al.
Clinica chimica acta; international journal of clinical chemistry, 304(1-2), 29-37 (2001-02-13)
The atherogenic lipoprotein Lp(a) consists of an LDL-like core and apo(a), linked to apoB via a thiol bridge. Apo(a) fragments ranging in size from 60 to 220 kDa are excreted into urine and the excretion rate correlates significantly with the
Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
Chen WQ, et al.
PLoS ONE, 8(8) (2013)
Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
Chen WQ, et al.
Testing, 8(8) (2013)

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