A5566
Monoclonal Anti-α1-Acid Glycoprotein antibody produced in mouse
clone AGP-47, ascites fluid
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About This Item
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
ascites fluid
Antikörper-Produkttyp
primary antibodies
Klon
AGP-47, monoclonal
Enthält
15 mM sodium azide
Speziesreaktivität
human, baboon (weakly)
Darf nicht reagieren mit
canine, bovine
Methode(n)
dot blot: suitable
indirect ELISA: suitable
western blot: 1:10,000
Isotyp
IgG1
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... ORM1(5004)
Allgemeine Beschreibung
Monoclonal Anti-α1-Acid Glycoprotein (mouse IgG1 isotype) is derived from the AGP-47 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. α1-Acid Glycoprotein (AGP) is an acute-phase plasma protein. This protein is mainly produced in the hepatocytes. AGP1 gene is mapped on the human chromosome at 9q32.
Spezifität
Recognizes an epitope located on the 44 kDa subunit of denatured-reduced AGP using the immunoblotting technique. It does not cross react with human serum amyloid P component, human haptoglobin, human C-reactive protein, and human IgG.
Immunogen
human α1-acid glycoprotein (AGP).
Biochem./physiol. Wirkung
α1-Acid Glycoprotein (AGP) associates with haptoglobin and C-reactive protein, which indicates inflammation. Higher levels of AGP is associated with various inflammatory diseases, trauma, malignancies, myocardial infarction, rheumatoid arthritis, after major surgery, and in cases of chronic pain. This protein is capable of binding and transporting basic and neutral drugs.
Physikalische Form
The product is provided as ascites fluid with 0.1% sodium azide as a preservative.
Lagerung und Haltbarkeit
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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B Crestani et al.
Journal of immunology (Baltimore, Md. : 1950), 160(9), 4596-4605 (1998-05-09)
Alpha1-acid glycoprotein (AGP) is a major acute phase protein in rat and human. AGP has important immunomodulatory functions that are potentially important for pulmonary inflammatory response. The liver is the main tissue for AGP synthesis in the organism, but the
Tino Hochepied et al.
Cytokine & growth factor reviews, 14(1), 25-34 (2002-12-18)
alpha(1)-Acid glycoprotein (AGP) is a protein with a molecular weight of 41-43 kDa and is heavily glycosylated (45%). Due to the presence of sialic acids, it is negatively charged (pI=2.7-3.2). AGP is an acute phase protein in all mammals investigated
Mosale Seetharam Sumanth et al.
Journal of leukocyte biology, 109(5), 915-930 (2020-10-19)
Alpha-1-acid glycoprotein (AGP-1) is a positive acute phase glycoprotein with uncertain functions. Serum AGP-1 (sAGP-1) is primarily derived from hepatocytes and circulates as 12-20 different glycoforms. We isolated a glycoform secreted from platelet-activating factor (PAF)-stimulated human neutrophils (nAGP-1). Its peptide
Lipocalin 2 in the pathogenesis of fatty liver disease and nonalcoholic steatohepatitis
Asimakopoulou A and Weiskirchen R
Clinical Lipidology, 10(1), 47-67 (2015)
Isabel Jaco et al.
Molecular cell, 66(5), 698-710 (2017-05-17)
TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase MK2, thereby promoting transcription, mRNA stabilization, and
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