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A0606

Sigma-Aldrich

Aurothioglukose

≥96% (titration)

Synonym(e):

Aurothioglucose

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About This Item

Empirische Formel (Hill-System):
C6H11AuO5S · xH2O
CAS-Nummer:
12192-57-3
Molekulargewicht:
392.18 (anhydrous basis)
EG-Nummer:
235-365-7
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24724383
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥96% (titration)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to beige

Löslichkeit

H2O: 5 mg/mL, clear

Lagertemp.

2-8°C

SMILES String

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1

InChIKey

SGVIEHTYEMEDRR-PKXGBZFFSA-M

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Anwendung

Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.

Biochem./physiol. Wirkung

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Leistungsmerkmale und Vorteile

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H317,H334

Gefahreneinstufungen

Resp. Sens. 1 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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M D Levin et al.
The Netherlands journal of medicine, 61(6), 223-225 (2003-09-19)
Thrombocytopenia is a well-known side effect following intramuscular gold therapy in patients with rheumatoid arthritis. Thrombocytopenia may occur at any time and it can be irreversible and sometimes fatal despite cytotoxic or immunosuppressive therapy. We describe two patients who presented
Au-Fe3O4 dumbbell nanoparticles as dual-functional probes.
Chenjie Xu et al.
Angewandte Chemie (International ed. in English), 47(1), 173-176 (2007-11-10)
Gabriela Maggioli et al.
The Journal of parasitology, 90(2), 205-211 (2004-05-29)
Thioredoxin reductase (TrxR), an enzyme belonging to the flavoprotein family of pyridine nucleotide-disulfide oxidoreductases, was isolated from the deoxycholate-soluble extract of the common liver fluke, Fasciola hepatica. Purification to homogeneity of the 60-kDa enzyme from the adult worm was achieved
KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery.
Beyrath J, et al.
Scientific Reports, 8 (2018)
K D Anderson et al.
Journal of neuroendocrinology, 15(7), 649-660 (2003-06-06)
Similar to leptin, ciliary neurotrophic factor (CNTF) suppresses appetite and selectively reduces body fat in leptin-deficient ob/ob mice. To assess the relative importance of specific regions of the hypothalamus in mediating these effects, we administered a CNTF analogue (CNTFAx15) or
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