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Merck

87128

Sigma-Aldrich

Tetracyclin

98.0-102.0% (HPLC)

Synonym(e):

Tetracycline HCL, Tetracycline Monohydrochloride

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About This Item

Empirische Formel (Hill-System):
C22H24N2O8 · xH2O
CAS-Nummer:
Molekulargewicht:
444.43 (anhydrous basis)
Beilstein:
2230417
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
51284017
PubChem Substanz-ID:
NACRES:
NA.85

Biologische Quelle

synthetic

Qualitätsniveau

Assay

98.0-102.0% (HPLC)

Form

powder or crystals

Farbe

faint yellow to dark yellow

mp (Schmelzpunkt)

172-174 °C (dec.)

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Wirkungsweise

protein synthesis | interferes

Lagertemp.

2-8°C

SMILES String

CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

InChIKey

OFVLGDICTFRJMM-WESIUVDSSA-N

Angaben zum Gen

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Allgemeine Beschreibung

Chemical structure: tetracycline

Biochem./physiol. Wirkung

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Verpackung

25g, 100g

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.

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Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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