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Merck

T8032

Sigma-Aldrich

Tetracyclin -hydrochlorid

powder

Synonym(e):

Tetracycline HCL

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About This Item

Empirische Formel (Hill-System):
C22H24N2O8 · HCl
CAS-Nummer:
Molekulargewicht:
480.90
Beilstein:
3844873
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
51284043
PubChem Substanz-ID:
NACRES:
NA.76

Biologische Quelle

synthetic

Qualitätsniveau

Sterilität

γ-irradiated

Form

powder

Wirksamkeit

≥850 μg per mg

Lagerbedingungen

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

Farbe

faintly yellow to yellow

mp (Schmelzpunkt)

220-223 °C (lit.)

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Wirkungsweise

protein synthesis | interferes

Lagertemp.

−20°C

SMILES String

Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1

InChIKey

XMEVHPAGJVLHIG-FMZCEJRJSA-N

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Allgemeine Beschreibung

Chemical structure: tetracycline

Anwendung

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L and in molecular biology applications at 10-20 μg/ml.

Biochem./physiol. Wirkung

Wirkungsweise: Inhibiert die Proteinsynthese (Elongation) durch Verhinderung des Bindens von Aminoacyl-tRNA an die 30S-Untereinheit.

Antimikrobielles Spektrum: Gram-negative und Gram-positive Bakterien.

Resistenzmechanismus: Verlust der Zellwandpermeabilität.

Verpackung

10MG,20MG

Vorsicht

This product should be frozen below 0°C and protected from light and moisture. In these conditions, the product has been shown to retain activity for 4 years. Stock solutions should be stored at -20°C and are stable at 37°C for 4 days.

Angaben zur Herstellung

The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Signalwort

Warning

Gefahreneinstufungen

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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