10385

Angiotensin III

≥98% (HPCE)

• Synonym(e): Des-Asp-1-Angiotensin II
• Empirische Formel (Hill-System): C₄₆H₆₆N₁₂O₉ · xC₂HF₃O₂ · yH₂O
• CAS-Nummer: 12687-51-3
• Molekulargewicht: 931.09 (anhydrous free base basis)
• Beilstein: 8385695
• MDL-Nummer: MFCD20264812
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 57646800
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPCE)
• Löslichkeit: H₂O: 1.0 mg/mL, clear, colorless
• Lagertemp.: −20°C
• SMILES String: O.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C46H66N12O9.C2HF3O2.H2O/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28;3-2(4,5)1(6)7;/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51);(H,6,7);1H2/t27-,32-,33-,34-,35-,36-,37-,38-;;/m0../s1
• InChIKey: JEOAJMGVSAMVML-UFPGTABSSA-N

Beschreibung

Amino Acid Sequence

Arg-Val-Tyr-Ile-His-Pro-Phe

Allgemeine Beschreibung

Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).

Biochem./physiol. Wirkung

Angiotensin III is an AT₁ and AT₂ agonist, with higher sensitivity for the AT₂ receptor. Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release and a stimulator for aldosterone release.

Leistungsmerkmale und Vorteile

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Antikörper-Adsorptionsmittel

Arg-Val-Tyr-Ile-His-Pro-Phe-OH.3CH₃COOH.4H₂O

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)