SMB01318

3-Hydroxydesloratadine

• Synonym(e): 3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
• Empirische Formel (Hill-System): C₁₉H₁₉ClN₂O
• CAS-Nummer: 119410-08-1
• Molekulargewicht: 326.82
• MDL-Nummer: MFCD00878381
• NACRES: NA.77

Eigenschaften

• Beschreibung: Modulation and Signaling
• Qualitätsniveau: 100
• Assay: ≥90%
• Form: solid
• Methode(n): HPLC: suitable
• Farbe: pale yellow to off-white
• Lagertemp.: −20°C
• InChI: 1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
• InChIKey: NDFMTPISBHBIKE-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.

Anwendung

3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research

Biochem./physiol. Wirkung

3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.

Leistungsmerkmale und Vorteile

• High quality compound suitable for multiple research applications
• Compatible with a wide variety of chromatographic and spectrometry techniques

Sonstige Hinweise

For additional information on our range of Biochemicals, please complete this form.

This product is intended for research purposes only, and it is not meant for human consumption.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable