SMB00963

7-Chlor-4-{[4-(ethylamino)-1-methylbutyl]amino}quinolin

≥95% (HPLC)

• Synonym(e): Monodesethylchloroqu​in
• Empirische Formel (Hill-System): C₁₆H₂₂ClN₃
• CAS-Nummer: 1476-52-4
• Molekulargewicht: 291.82
• MDL-Nummer: MFCD00871808
• UNSPSC-Code: 41116107
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 200
• Qualität: research grade
• Assay: ≥95% (HPLC)
• Form: powder or crystals
• Methode(n): HPLC: suitable
• Farbe: white to off-white
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• SMILES String: ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2
• InChI: 1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)
• InChIKey: MCYUUUTUAAGOOT-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Desethylchloroquine is a metabolite of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine have antimalarial properties and are used as a therapeutic for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. They have also been in the spotlight due to their activity on patients with COVID-19, the disease caused by the SARS-CoV-2 virus. Hydroxychloroquine and chloroquine interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production. Their mode of action is still emerging and their metabolism is of great interest.

Anwendung

Application: Metabolomics research

Sonstige Hinweise

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Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable