SMB00975

Bisdesethylchloroquine Hydrochloride

• Synonym(e): Bisdesethyl chloroquine hydrochloride, Didesethylchloroquine hydrochloride
• Empirische Formel (Hill-System): C₁₄H₁₈ClN₃ · xHCl
• Molekulargewicht: 263.77 (free base basis)
• MDL-Nummer: MFCD00871854
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Qualitätsniveau: 200
• Form: solid
• Lagertemp.: 2-8°C
• SMILES String: Clc1cc2nccc(c2cc1)NC(CCCN)C
• InChI: 1S/C14H18ClN3/c1-10(3-2-7-16)18-13-6-8-17-14-9-11(15)4-5-12(13)14/h4-6,8-10H,2-3,7,16H2,1H3,(H,17,18)

Beschreibung

Allgemeine Beschreibung

Bisdesethylchloroquine is an immediate metabolite of hydroxychloroquine and chloroquine. These are antimalarial drugs used clinically in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production and certain co-stimulatory molecules. Hydroxychloroquine and chloroquine mode(s) of action are still emerging and their metabolism are of great interest. Metabolic Pathway: Cytochrome P450 drug.

Anwendung

Metabolomics research

Sonstige Hinweise

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Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable