PHR1700

Ribavirin

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): Ribavirin, 1-β-D-Ribofuranosyl-1,2,4-triazol-3-carboxamid
• Empirische Formel (Hill-System): C₈H₁₂N₄O₅
• CAS-Nummer: 36791-04-5
• Molekulargewicht: 244.20
• MDL-Nummer: MFCD00058564
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823563
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to BP 593; traceable to Ph. Eur.; traceable to USP 1602706
• API-Familie: ribavirin
• Analysenzertifikat (CofA): current certificate can be downloaded
• Verpackung: pkg of 1 g
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
• InChI: 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
• InChIKey: IWUCXVSUMQZMFG-AFCXAGJDSA-N
• Angaben zum Gen: human ... IMPDH1(3614)

Beschreibung

Allgemeine Beschreibung

Analog den Imidazol-Nukleotid-Zwischenprodukten in der Purin-Nukleotid-Biosynthese.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Anwendung

Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Virostatikum, das gegen eine Vielzahl von humanen Virusinfektionen verwendet wird, insbesondere chronischer Hepatitis C, HIV und Adenovirus. Sein Metabolit Ribavirin-5′-phosphat inhibiert Inosinmonophosphat (IMP)-Dehydrogenase, aber auch viele andere Wirkmechanismen sind durch experimentelle Beweise gestützt.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H341,H360FD
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Muta. 2 - Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable