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PHR1040

Supelco

Naproxen

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

(S)-(+)-2-(6-Methoxy-2-naphthyl)-propionsäure, (S)-(+)-6-Methoxy-α-methyl-2-naphthylessigsäure

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About This Item

Lineare Formel:
CH3OC10H6CH(CH3)CO2H
CAS-Nummer:
Molekulargewicht:
230.26
Beilstein:
3591068
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to BP 435
traceable to Ph. Eur. N0250000
traceable to USP 1457301

API-Familie

naproxen

Analysenzertifikat (CofA)

current certificate can be downloaded

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

152-154 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O

InChI

1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1

InChIKey

CMWTZPSULFXXJA-VIFPVBQESA-N

Angaben zum Gen

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Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Naproxen belongs to the class of arylacetic acids and is used as a non-steroidal anti-inflammatory drug (NSAID). It is useful for the management of pain, inflammation and stiffness. It is also used in the treatment of rheumatoid arthritis and other painful musculoskeletal disorders.

Anwendung

Naproxen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC) technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Nicht selektiver Cyclooxygenase (COX-1 und COX-2) Inhibitor.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

Dieses Produkt wurde für Genauigkeit und Stabilität gemäss den Normen ISO / IEC 17025:2005, (AClass Cert AT-1467) und ISO GUIDES 34:2009 (AClass Cert AR-1470) produziert und geprüft.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA8968 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3


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Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Simultaneous determination of naproxen, ketoprofen and phenol red in samples from rat intestinal permeability studies: HPLC method development and validation
Zakeri-Milani P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 39(3-4), 624-630 (2005)
High performance liquid chromatography with photo diode array for separation and analysis of naproxen and esomeprazole in presence of their chiral impurities: enantiomeric purity determination in tablets
Ragab MAA and Eman I
Journal of Chromatography A, 1497, 110-117 (2017)
J Rossat et al.
Clinical pharmacology and therapeutics, 66(1), 76-84 (1999-08-03)
To compare the renal hemodynamic and tubular effects of celecoxib, a selective inhibitor of cyclooxygenase-2 (COX-2) to those of naproxen, a nonselective inhibitor of cyclooxygenases in salt-depleted subjects. Forty subjects were randomized into four parallel groups to receive 200 mg
J Sieper et al.
Annals of the rheumatic diseases, 73(1), 101-107 (2013-05-23)
To assess whether combination therapy with infliximab (IFX) plus nonsteroidal anti-inflammatory drugs (NSAIDs) is superior to NSAID monotherapy for reaching Assessment of SpondyloArthritis international Society (ASAS) partial remission in patients with early, active axial spondyloarthritis (SpA) who were naïve to
J I Schwartz et al.
Clinical pharmacology and therapeutics, 72(1), 50-61 (2002-08-02)
This study compared directly the renal effects of two selective cyclooxygenase (COX)-2 inhibitors (rofecoxib and celecoxib) with naproxen (dual COX-1/COX-2 inhibitor) and placebo in healthy elderly subjects on a sodium-replete diet. A total of 67 elderly subjects stabilized in the

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