251680

Dantrolene, Sodium Salt

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.

• Synonym(e): Dantrolene, Sodium Salt
• Empirische Formel (Hill-System): C₁₄H₉N₄O₅ · Na
• CAS-Nummer: 14663-23-1
• Molekulargewicht: 336.23
• MDL-Nummer: MFCD00079130
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Farbe: orange
• Löslichkeit: DMSO: 3 mg/mL; aqueous base: soluble
• Versandbedingung: ambient
• Lagertemp.: 10-30°C
• InChI: 1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
• InChIKey: KSRLIXGNPXAZHD-HAZZGOGXSA-M

Beschreibung

Allgemeine Beschreibung

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission. Has neuroprotective effects in cases of cerebral ischemia.

A skeletal muscle relaxant. Blocks intracellular calcium release from the sarcoplasmic reticulum during excitation-contraction coupling by binding to the ryanodine receptor. Blocks long-term depression and depotentiation.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
Ryanodine receptor

Product does not compete with ATP.

Reversible: no

Warnhinweis

Toxicity: Harmful (C)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Wei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
O’Mara, S.M., et al. 1995. Neuroscience68, 621.
Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem.270, 18465.
Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA91, 3039.
Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3039.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable